Preferred Label : Extended Release Flucytosine;
NCIt synonyms : Extended Release 5-Fluorocytosine; Extended Release 5-FC; Extended-Release 5-Fluorocytosine; Extended-Release Flucytosine; Extended-Release 5-FC;
NCIt definition : An extended release (ER) oral tablet that contains flucytosine (5-FC), a fluorinated
cytosine analog, with antifungal activity and potential anti-cancer activity. Following
oral administration of ER 5-FC, the 5-FC is deaminated to its active metabolite 5-fluorouracil
(5-FU). 5-FU replaces uracil during RNA synthesis, which consequently inhibits downstream
protein synthesis. In addition, 5-FU is metabolized further to 5-fluorodeoxyuridylic
acid monophosphate, which inhibits thymidylate synthetase. Inhibition of this enzyme
interrupts nucleotide synthesis, DNA replication and cell proliferation. Negative
regulation of protein synthesis, DNA replication and cell proliferation can lead to
cell death. Following ingestion of ER 5-FC, intravenous injection of a retroviral
vector encoding cytosine deaminase (TC 511) at a tumor site may result in higher local
concentrations of 5-FU and its metabolites, and increased tumor cell death than other
5-FU treatment regimens.;
Drug name : Toca FC;
NCI Metathesaurus CUI : CL454672;
Origin ID : C112498;
UMLS CUI : C3830286;
Semantic type(s)
- concept_is_in_subset
- has_target
