NCIt related terms : Efudex; Arumel; Timazin; Fluoroplex;
NCIt definition : A topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic
activity. Upon topical administration, 5-FU is converted into the active metabolite
5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis
and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate
(F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine
triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis,
and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor
cells locally.;
Drug name : Flurox; Efudex; Arumel; Fiverocil; Timazin; Efurix; Cytosafe; Fluoroplex; Actino-Hermal; Carac; Tolak;
Semantic type(s)