https://www.has-sante.fr/jcms/p_3194755/fr/definition-des-conditions-de-realisation-des-tests-de-detection-des-mutations-activatrices-de-l-egfr-et-des-mutations-braf-nras-et-kras 2021 France health technology assessment mutation acyclovir ErbB Receptors achievement mutation activir EGF Receptors detective Gain of Function Mutation