Preferred Label : Anti-HER2 Dendritic Cell Vaccine;
NCIt synonyms : Anti-HER2 DC Vaccine; Anti-HER2 DC1 Vaccine; HER2-primed DC1 Vaccine; HER2-primed DC Vaccine; HER2-primed Dendritic Cell Vaccine; Anti-HER-2 DC Vaccine;
NCIt definition : A type-1-polarized dendritic cell (DC1)-based cancer vaccine against the tumor-associated
antigen (TAA) human epidermal growth factor receptor 2 (HER2; EGFR2, ERBB2), with
potential immunomodulatory and antineoplastic activities. Upon intratumoral administration
of the anti-HER2 DC vaccine, the immune system gets exposed to HER2, which may stimulate
a potent cytotoxic T-lymphocyte (CTL) response against HER2-positive tumor cells.
This may result in tumor cell death and decreased tumor growth. HER2, a member of
the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is
overexpressed by a variety of cancers.;
NCI Metathesaurus CUI : CL1794191;
Origin ID : C189230;
UMLS CUI : C5708324;
Semantic type(s)
- concept_is_in_subset
- has_target
