Preferred Label : Zanidatamab Zovodotin;
NCIt synonyms : ADC ZW49; Anti-HER2 Bispecific ADC ZW49;
NCIt definition : An antibody-drug conjugate (ADC) consisting of zanidatamab, a bispecific immunoglobin
G1 (IgG1) monoclonal antibody directed against two different epitopes of the tumor-associated
antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) conjugated,
via a protease-cleavable linker, to ZD02044, a microtubule-disrupting cytotoxic auristatin,
with potential antineoplastic activity. Upon intravenous administration, zanidatamab
zovodotin targets and binds to HER2 expressed on tumor cells. Following receptor internalization,
ZD02044 is released. It then binds to tubulin and inhibits its polymerization, which
results in G2/M phase arrest and induces apoptosis of HER2-expressing tumor cells.
Additionally, binding of HER2 may inhibit HER2 activation, HER2 signaling and HER2-mediated
tumor cell growth. HER2, a receptor tyrosine kinase that is mutated or overexpressed
in many tumor cell types, plays an important role in tumor cell proliferation and
tumor vascularization.;
UNII : HKH2GV9PVO;
CAS number : 2329698-82-8;
Molecule name : ZW-49;
NCI Metathesaurus CUI : CL1413083;
Origin ID : C175879;
UMLS CUI : C5446814;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_target
