Preferred Label : pNGVL3-hICD Vaccine AST-301;
NCIt synonyms : pNGVL3-hICD Plasmid DNA-based Vaccine AST-301; Therapeutic Cancer Vaccine AST-301; Plasmid DNA-based Vaccine Expressing HER2/neu ICD AST-301; HER-2/neu ICD Therapeutic Cancer Vaccine AST-301;
NCIt definition : A plasmid DNA therapeutic cancer vaccine encoding the intracellular domain (ICD) of
the HER-2/neu proto-oncogene, with potential immunomodulating and antineoplastic activities.
Upon administration, the pNGVL3-hICD vaccine AST-301 expresses the HER-2/neu protein
and elicits a HER-2-specific cytotoxic T-lymphocyte (CTL) immune response against
tumor cells expressing HER-2. The HER-2/neu ICD protein is highly immunogenic and,
as a subdominant epitope, may be associated with decreased immune tolerance.;
Molecule name : AST 301; EP301; EP 301; AST-301;
NCI Metathesaurus CUI : CL1799381;
Origin ID : C190734;
UMLS CUI : C5783891;
Semantic type(s)
- concept_is_in_subset
- has_target
