Preferred Label : Lead Pb 212 TCMC-trastuzumab;
NCIt synonyms : [212]Pb TCMC-Herceptin; Lead Pb 212 TCMC-Herceptin; [212]Pb TCMC-trastuzumab;
NCIt definition : A radioimmunoconjugate containing the recombinant humanized monoclonal antibody trastuzumab
conjugated with the bifunctional chelating agent TCMC ((1,4,7,10-Tetra-(2-Carbamoyl
Methyl)-Cyclododecane), and radiolabeled with the alpha-emitting isotope lead Pb 212,
with potential anti-tumor activity. Upon administration, the antibody moiety of lead
Pb 212 TCMC-trastuzumab binds with high affinity to the extracellular domain of human
epidermal growth factor receptor 2 (HER2); after internalization, the radioisotope
moiety delivers a cytotoxic dose of alpha radiation to the HER2-expressing tumor cells.
HER2, a tyrosine kinase receptor, is overexpressed on the cell surface of a variety
of cancer cell types.;
NCI Metathesaurus CUI : CL430248;
Origin ID : C97500;
UMLS CUI : C3273448;
Semantic type(s)
- concept_is_in_subset
- has_target
