Preferred Label : Anti-HER2/CD3 Tri-specific Antibody BR115;
NCIt synonyms : Trispecific Antibody BR115; Tri-specific TCE BR115; Anti-CD3/Anti-HER2 Tri-specific Antibody BR115; Tri-specific T-cell Engager BR115;
NCIt definition : A tri-specific T-cell engager and monoclonal antibody targeting two separate epitopes
of the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2) and the T-cell surface antigen CD3, with potential immunomodulating and
antineoplastic activities. Upon intravenous administration, anti-HER2/CD3 tri-specific
antibody BR115 targets and binds to two separate HER2 epitopes on HER2-expressing
tumor cells and CD3 on T-cells. The resulting cross-linkage may trigger a potent cytotoxic
T-lymphocyte (CTL) response against HER2-expressing tumor cells. HER2, a receptor
tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key
role in tumor cell proliferation and tumor vascularization.;
Molecule name : BR-115; BR 115;
Origin ID : C209759;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
