NCIt definition : A bispecific monoclonal antibody directed against the human epidermal growth factor
receptors ErbB2 (Her2) and ErbB3 (Her3) with potential antineoplastic activity. The
anti-ErB2 targeting arm of anti-ErbB2/anti-ErbB3 bispecific monoclonal antibody MM-111
binds to ErbB2 on tumor cells with high affinity while the anti-Erb3 therapeutic arm
binds to ErbB3, which may result in the inhibition of cellular proliferation and differentiation
in ErbB2-overexpressing tumor cells via inhibition of ErbB3-dependent signal transduction
pathways. ErbB2 and ErB3 are members of the epidermal growth factor receptor (EGFR)
family of receptor tyrosine kinases and are frequently overexpressed in solid tumors.;
UNII : 6IJ4CQY76O;
CAS number : 1361108-53-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1361108-53-3
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Semantic type(s)