NCIt definition : A preparation of autologous, interleukin-7 (IL-7)-expanded, human epidermal growth
factor receptor 2 (EGFR2; HER2; ErbB2)-specific, cluster of differentiation 4 (CD4)-positive
T-lymphocytes, with potential immunostimulating and antineoplastic activities. Autologous
HER2-specific CD4 T-cells are expanded ex vivo with IL-7. Upon reintroduction into
the patient, the autologous IL-7-expanded HER2-specific CD4 T-cells recognize and
stimulate a T-cell-mediated immune response against HER2-expressing tumor cells. HER2,
a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types,
plays a key role in tumor cell proliferation and tumor vascularization. IL-7 is a
cytokine that promotes the proliferation and survival of T-cells.;