NCIt definition : A population of autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to
human adenovirus (Ad) that have been transduced with a retroviral vector expressing
a second-generation human epidermal growth factor receptor type 2 (HER2; EGFR2; ErbB2)-specific
chimeric antigen receptor (CAR) comprised of an exodomain based on a anti-CD22 single
chain variable fragment (scFv) from the anti-HER2 monoclonal antibody FRP5 that is
linked to the costimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex
(CD3zeta), with potential immunostimulating and antineoplastic activities. Upon intravenous
administration, the autologous HER2-CAR-modified Ad-specific CTLs are directed to
and induce selective toxicity in HER2-expressing tumor cells. Additionally, these
cells may help reconstitute Ad-specific CTL responses in immunocompromised individuals
and others at risk of developing Ad-infection. HER2, a receptor tyrosine kinase (RTK)
overexpressed by a variety of tumor cell types, belongs to the EGFR superfamily and
plays a key role in tumor cell proliferation.;