NCIt synonyms : HER2 x CD3 Bispecific Antibody M802;
NCIt definition : A humanized bispecific antibody composed of a monovalent unit directed against the
tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2)
and a single chain unit directed against CD3 found on T-lymphocytes, with potential
immunostimulatory and antineoplastic activities. Upon administration, anti-HER2/anti-CD3
bispecific antibody M802 binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and HER2
on HER2-expressing tumor cells. This activates and redirects CTLs to HER2-expressing
tumor cells, which results in the CTL-mediated cell death of HER2-expressing tumor
cells. HER2 is overexpressed in a variety of cancer cell types and is associated with
increased tumor cell proliferation.;
Semantic type(s)