Preferred Label : Iodine I 131 SGMIB-Anti-HER2 CAM-H2;
NCIt synonyms : Iodine I 131 N-succinimidyl 4-guanidinomethyl-3-iodobenzoate-Anti-HER2 VHH1; [131I]-SGMIB Anti-HER2 VHH1; I-131-VHH1; Iodine I 131 SGMIB-Anti-HER2 sdAb 2Rs 15d; I-131-CAMH2; I-131-CAM-H2; I-131-CAM H2; Iodine I 131 SGMIB-Anti-HER2 VHH1;
NCIt definition : A radioconjugate composed of a camelid single domain antibody (sdAb) CAM-H2 (VHH1;
sdAb 2Rs 15d) directed against human epidermal growth factor receptor 2 (HER2, EGFR2,
ERBB2) that is covalently linked via N-succinimidyl 4-guanidinomethyl-3-iodobenzoate
(SGMIB) to the radionuclide iodine I 131, with radioimaging and antineoplastic activities.
Upon administration of iodine I 131 SGMIB-anti-HER2 CAM-H2, the anti-HER2 antibody
moiety targets and binds to HER2-expressing cells. This facilitates both the detection
of HER2-expressing tumor cells and the targeted destruction of HER2-positive tumors.
HER2, a tyrosine kinase is overexpressed on the cell surfaces of various tumor cell
types. CAM-H2 is composed of small (15 kDa), heavy chain-only anti-HER2 antibody fragments
that are able to cross the blood-brain barrier (BBB) and are thus potentially useful
in the treatment of central nervous system (CNS) metastases.;
NCI Metathesaurus CUI : CL504846;
Origin ID : C126269;
UMLS CUI : C5783363;
Semantic type(s)
- concept_is_in_subset
- has_target
