Preferred Label : Anti-HER2/HER3 Dendritic Cell Vaccine;
NCIt synonyms : Anti-HER2/3 DC Vaccine; Anti-HER2/3 Dendritic Cell Vaccine;
NCIt definition : A dendritic cell (DC)-based cancer vaccine against the tumor-associated antigens (TAAs)
human epidermal growth factor receptor 2 (HER2; EGFR2, ERBB2) and 3 (HER3; ErbB3),
with potential immunomodulatory and antineoplastic activities. Upon administration
of the anti-HER2/HER3 DC vaccine, the immune system gets exposed to HER2 and HER3,
which may stimulate a potent cytotoxic T-lymphocyte (CTL) response against HER-2/3-positive
tumor cells. This may result in tumor cell death and decreased tumor growth. HER-2/3,
members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine
kinases, are overexpressed by a variety of cancers.;
NCI Metathesaurus CUI : CL1383088;
Origin ID : C170932;
UMLS CUI : C5418886;
Semantic type(s)
- concept_is_in_subset
- has_target
