NCIt definition : A peptide vaccine containing four immunogenic epitopes derived from the tumor-associated
antigen (TAA) human epidermal growth factor receptor 2 (HER2; HER-2; ErbB2; Neu),
with potential immunomodulating and antineoplastic activities. Upon intradermal administration,
multi-epitope HER2 peptide vaccine H2NVAC may induce a helper T-cell mediated immune
response against HER2-overexpressing tumor cells. This may result in long-term immunopotentiation
against HER2-expressing tumor cells by increasing the helper T-cell response. HER2,
a tyrosine kinase receptor for epidermal growth factor (EGF), is overexpressed in
various cancer cell types.;
Semantic type(s)