Preferred Label : GP2 Peptide/GM-CSF Vaccine;
NCIt definition : A vaccine containing a HER2/Neu-derived epitope (amino acids 654-662) (GP2), and combined
with granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential antineoplastic
and immunoadjuvant activity. Upon vaccination, GP2 may activate the immune system
to mount a cytotoxic T-lymphocyte (CTL) immune response against HER2/Neu expressing
cancer cells. GM-CSF may potentiate a tumor-specific cytotoxic T-lymphocyte (CTL)
response against cancer cells expressing the HER2/Neu antigen. HER2/neu, a tumor associated
antigen (TAA), is overexpressed in a variety of tumor cell types and is highly immunogenic.;
NCI Metathesaurus CUI : CL376183;
Origin ID : C91720;
UMLS CUI : C2984511;
Semantic type(s)
- concept_is_in_subset
- has_target
