Preferred Label : Technetium Tc-99m-MIRC213;
NCIt synonyms : Technetium Tc 99m-MIRC213; 99mTc-MIRC213;
NCIt definition : A radioconjugate composed of a nanobody directed against human epidermal growth factor
receptor 2 (HER2; EGFR2; ERBB2) that is site-specifically labeled with technetium
Tc 99m, with potential use as a tracer for HER2-expressing tumors using single photon
emission computed tomography/computed tomography (SPECT/CT). Upon administration of
technetium Tc-99m-MIRC213, the anti-HER2 nanobody moiety targets and binds to HER2-expressing
tumor cells. This allows the detection of HER2-expressing tumor cells upon SPECT/CT.
HER2, a receptor tyrosine kinase, is overexpressed on the cell surfaces of various
tumor cell types; it plays a key role in tumor cell proliferation and tumor vascularization.;
NCI Metathesaurus CUI : CL1905843;
Origin ID : C198693;
UMLS CUI : C5855043;
Semantic type(s)
- concept_is_in_subset
- has_target
