Preferred Label : Anti-HER2/Topoisomerase I Inhibitor ADC TQB2102;
NCIt synonyms : Anti-HER2 ADC TQB2102; Anti-HER2/Topoisomerase I Inhibitor Antibody-drug Conjugate TQB2102; ADC TQB2102;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against the tumor-associated antigen (TAA) human epidermal growth factor receptor
2 (EGFR2; HER2; ErbB2) conjugated, via an enzyme-cleavable linker, to a topoisomerase
I (TopoI) inhibitor payload, with potential antineoplastic activity. Upon administration
of the anti-HER2/topoisomerase I inhibitor ADC TQB2102, the anti-HER2 monoclonal antibody
moiety targets and binds to HER2 expressed on tumor cells. Upon cellular uptake, the
TopoI inhibitor inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
which results in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of HER2-expressing tumor cells. HER2, a tyrosine kinase receptor, is overexpressed
by many cancer cell types.;
Molecule name : TQB 2102; TQB-2102;
NCI Metathesaurus CUI : CL1907123;
Origin ID : C200318;
UMLS CUI : C5854521;
Semantic type(s)
- concept_is_in_subset
- has_target
