" /> Anvatabart Opadotin - CISMeF





Preferred Label : Anvatabart Opadotin;

NCIt synonyms : ADC ARX788; Anti-HER2 ADC ARX788; Anti-HER2 Antibody-drug Conjugate ARX788; Anti-Her2 Mab PAF- MMAF Toxin Oxime Conjugate ARX-788;

NCIt definition : An antibody-drug conjugate (ADC) composed of anvatabart, a monoclonal antibody targeting human epidermal growth factor receptor 2 (EGFR2; HER2) site-specifically conjugated at two engineered residues of para-acetyl-phenylalanine (pAcF) via a stable oxime linker to the monomethyl auristatin F (MMAF) analog and potent microtubule inhibitor opadotin, with potential antineoplastic activity. Upon administration of anvatabart opadotin, the antibody moiety targets and binds to HER2 on tumor cells. Upon antibody/antigen binding and internalization, opadotin binds to and inhibits tubulin polymerization, which results in G2/M phase arrest and tumor cell apoptosis. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. The site-specific conjugation of the cytotoxic agent to the antibody improves the biophysical properties of anvatabart opadotin, increases payload stability and optimizes its efficacy.;

UNII : B2KH16FA7H;

CAS number : 2636710-07-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2636710-07-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ARX788;

NCI Metathesaurus CUI : CL498281;

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11/05/2024


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