Preferred Label : Anti-HER2 Immune Stimulator-antibody Conjugate NJH395;
NCIt synonyms : Anti-HER2 ISAC NJH395;
NCIt related terms : NJH-395;
NCIt definition : An immune stimulator-antibody conjugate (ISAC) composed of a monoclonal antibody targeting
human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2) conjugated to a not
yet disclosed immune stimulator, with potential antineoplastic and immunostimulating
activities. Upon administration of the anti-HER2 immune stimulator-antibody conjugate
NJH395, the antibody moiety targets and binds to HER2 expressed on tumor cells. Upon
antibody/antigen binding, the immune-stimulating moiety may, through an as of yet
undisclosed mechanism, enhance the immune-mediated killing of HER2-expressing tumor
cells. HER2, a tyrosine kinase receptor, is overexpressed in many cancer types and
plays a key role in tumor cell proliferation and tumor vascularization.;
UNII : 301EY96MDU;
Molecule name : NJH-395; NJH 395;
NCI Metathesaurus CUI : CL969413;
Origin ID : C160349;
UMLS CUI : C5205167;
Semantic type(s)
- concept_is_in_subset
- has_target
