Preferred Label : Thorium Th 227 Trastuzumab Corixetan;
NCIt synonyms : Thorium-227 Anti-HER2 Monoclonal Antibody BAY2701439; Th-227-Anti-HER2 Monoclonal Antibody BAY2701439; Thorium Th 227 MOAB BAY2701439; 227Th Anti-HER2 Monoclonal Antibody BAY2701439; Th 227 Anti-HER2 Monoclonal Antibody BAY2701439; Thorium Th 227 Monoclonal Antibody BAY2701439; HER2-TTC; 227Th Trastuzumab Corixetan; Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439;
NCIt related terms : TRASTUZUMAB CORIXETAN THORIUM TH-227;
NCIt definition : A radioimmunoconjugate consisting of trastuzumab, a monoclonal antibody targeting
the tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2), conjugated
to the chelating agent corixetan, and labeled with the alpha-emitting radioisotope
thorium Th 227, with potential antineoplastic activity. Upon administration of thorium
Th 227 trastuzumab corixetan, the trastuzumab moiety targets and specifically binds
to HER2 on tumor cells, thereby delivering a cytotoxic dose of alpha radiation to
cells expressing HER2. HER2 is overexpressed in a variety of cancer cell types and
is associated with increased tumor cell proliferation.;
UNII : QC6MLG1NN6;
Molecule name : BAY 2701439; BAY-2701439;
NCI Metathesaurus CUI : CL1378806;
Origin ID : C168996;
UMLS CUI : C5706662;
Semantic type(s)
- concept_is_in_subset
- has_target
