Autologous IL-15-expanded HER2-specific CD4 T-cells

Preferred Label : Autologous IL-15-expanded HER2-specific CD4 T-cells;

NCIt synonyms : Autologous IL-15-expanded HER2-specific CD4 T-lymphocytes; Autologous IL-15 Expanded HER2-specific CD4 T Cells;

NCIt definition : A preparation of autologous, interleukin-15 (IL-15)-expanded, human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2)-specific, cluster of differentiation 4 (CD4)-positive T-lymphocytes, with potential immunostimulating and antineoplastic activities. Autologous HER2-specific CD4 T-cells are expanded ex vivo with IL-15. Upon reintroduction into the patient, the autologous IL-15-expanded HER2-specific CD4 T-cells recognize and stimulate a T-cell-mediated immune response against HER2-expressing tumor cells. HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. IL-15 is a cytokine that enhances T-cell expansion.;

NCI Metathesaurus CUI : CL1792366;

Details

Origin ID

C187685;

UMLS CUI

C5707291;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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