Preferred Label : AE37 Peptide/GM-CSF Vaccine;
NCIt synonyms : AE-37 Peptide/GM-CSF Vaccine;
NCIt definition : A vaccine containing HER2/Neu-derived epitope (amino acids 776-790) linked to li-Key
peptide (li-Key/HER2/neu hybrid peptide or AE37), and combined with granulocyte-macrophage
colony-stimulating factor (GM-CSF), with potential antineoplastic and immunoadjuvant
activities. Upon vaccination, AE37 may activate the immune system and stimulate T-helper
cells against HER2/Neu expressing cancer cells. GM-CSF may potentiate the immune response
against cancer cells expressing the HER2/Neu antigen. The Ii-Key moiety, a 4-amino
acid (LRMK) epitope from the MHC class II-associated invariant chain (Ii protein),
increases T-helper cell stimulation against HER2/neu antigen when compared to unmodified
class II epitopes. HER2/neu, a tumor associated antigen (TAA), is overexpressed in
a variety of tumor cell types and is highly immunogenic.;
NCI Metathesaurus CUI : CL376182;
Origin ID : C91719;
UMLS CUI : C2984510;
Semantic type(s)
- concept_is_in_subset
- has_target
