Preferred Label : Autologous Anti-HER2 CAR Macrophages CT-0508;
NCIt synonyms : Autologous Anti-HER2-CAR-expressing Macrophages CT-0508; Autologous Ad5f35-transduced Anti-HER2 CAR-M CT-0508; Autologous Anti-HER2 CAR-M CT-0508; CAR-M CT-0508;
NCIt definition : A preparation of autologous macrophages transduced with the adenoviral vector Ad5f35
to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen
(TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), with potential
immunostimulatory and antineoplastic activities. Upon administration, autologous anti-HER2
CAR Macrophages (CAR-M) CT-0508 specifically recognize and bind to HER2-expressing
tumor cells, resulting in the phagocytosis of HER2-expressing tumor cells. CAR-M CT-0508
maintain the pro-inflammatory, anti-tumor M1 phenotype within the human tumor microenvironment
(TME). In addition, CAR-M CT-0508 may activate an anti-tumor T-lymphocyte immune response
resulting in T-cell-mediated killing of tumor cells. HER2, a receptor tyrosine kinase
that is mutated or overexpressed in many tumor cell types, plays an important role
in tumor cell proliferation and tumor vascularization.;
Molecule name : CT 0508; CT-0508;
NCI Metathesaurus CUI : CL1642593;
Origin ID : C176824;
UMLS CUI : C5447453;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
