Preferred Label : pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine;
NCIt synonyms : pUMVC3-IGFBP2-HER2-IGF1R Vaccine; WOKVAC Vaccine; pUMVC3-IGFBP2-HER2-IGF1R; WOKVAC;
NCIt definition : A polyepitope plasmid DNA vaccine containing the mammalian expression vector pUMVC3
encoding epitopes derived from three tumor-associated antigens (TAAs): human insulin-like
growth factor-binding protein 2 (IGFBP2), human epidermal growth factor receptor 2
(HER2; ERBB2) and insulin-like growth factor 1 receptor (IGF1R), with potential immunostimulating
and antineoplastic activities. Upon intradermal vaccination, pUMVC3-IGFBP2-HER2-IGF1R
plasmid DNA vaccine transfects local keratinocytes, which process the plasmid, express
the epitopes and present them to antigen-presenting cells (APCs). This activates the
immune system to mount a combined response from specific T helper type 1 (Th1) cells,
memory T-cells and cytotoxic T-lymphocytes (CTL) against IGFBP2-, HER2-, and IGF1R-expressing
tumor cells. IGFBP2, HER2, and IGF1R are tumor-associated proteins overexpressed in
certain tumor cell types, and play key roles in cellular proliferation and survival.;
NCI Metathesaurus CUI : CL507933;
Origin ID : C127910;
UMLS CUI : C4287951;
Semantic type(s)
- concept_is_in_subset
- has_target
