NCIt definition : A cancer peptide vaccine comprised of the epitope GP2, a nine amino acid peptide (amino
acids 654-662) derived from the tumor-associated antigen (TAA) HER2/neu (ErbB-2) and
the immune-adjuvant granulocyte macrophage-colony-stimulating factor (GM-CSF), with
potential immunomodulating and antineoplastic activities. Upon intradermal administration
of the HER2/neu peptide vaccine GLSI-100, GP2 may induce a cytotoxic T-lymphocyte
(CTL)-mediated immune response against tumor cells expressing the HER2/neu antigen,
which may result in the inhibition of proliferation of HER2/neu-expressing tumor cells.
HER2/neu, a member of the epidermal growth factor receptor (EGFR) family of tyrosine
kinases, is overexpressed in various tumor cell types. GM-CSF enhances the CTL-mediated
immune response against HER2/neu.;
Semantic type(s)