Preferred Label : HER2 Tri-specific Natural Killer Cell Engager DF1001;
NCIt synonyms : HER2 Tri-specific NK Cell Engager DF1001; Tri-specific NK Cell Engager DF1001; Tri-specific Natural Killer Cell Engager DF1001;
NCIt definition : An engineered molecule based on tri-specific natural killer (NK) cell engager therapies
(TriNKET) that is directed against human epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2), with potential immunostimulating and antineoplastic activities. Upon
administration, HER2 tri-specific NK cell engager DF1001 targets and binds to HER2
on tumor cells and simultaneously binds to NK cells, thereby bringing HER2-expressing
tumor cells and NK cells together, which stimulates the NK cells and results in the
selective NK cell-mediated tumor cell lysis of HER2-expressing tumor cells. The binding
of HER2-expressing tumor cells and NK cells may also lead to the activation of T-cells
and B-cells, potentiating the immune response against HER2-expressing tumor cells.
HER2, a receptor tyrosine kinase (RTK) mutated or overexpressed in many tumor cell
types, plays a key role in tumor cell proliferation and tumor vascularization.;
Molecule name : DF 1001; DF-1001;
NCI Metathesaurus CUI : CL1406166;
Origin ID : C172279;
UMLS CUI : C5417910;
Semantic type(s)
- concept_is_in_subset
- has_target
