NCIt synonyms : HER2 Inhibitor BI 1810631; HER-2 Inhibitor BI 1810631;
NCIt definition : An orally bioavailable inhibitor of the receptor tyrosine kinase human epidermal growth
factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. Upon
oral administration, zongertinib covalently binds to and inhibits the activity of
both wild-type and HER2 mutants, including HER2 mutants with exon 20 insertion (ex20ins)
mutations. This prevents HER2-mediated signaling and may lead to cell death in HER2-expressing
tumor cells. HER2, a receptor tyrosine kinase overexpressed on a variety of tumor
cell types, plays an important role in tumor cell proliferation and tumor vascularization.;
Currated CISMeF NLP mapping