Preferred Label : Anti-HER2 Antibody-drug Conjugate BL-M07D1;
NCIt synonyms : Anti-HER2 ADC BL-M07D1;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2) linked to an undisclosed cytotoxic agent, with potential antineoplastic
activity. Upon administration of anti-HER2 ADC BL-M07D1, the anti-HER2 monoclonal
antibody moiety targets and binds to HER2 expressed on tumor cells. Upon binding and
internalization, the cytotoxic agent is released and kills HER2-expressing tumor cells
through an as of yet undisclosed mechanism. HER2, a receptor tyrosine kinase that
is mutated or overexpressed in many tumor cell types, plays an important role in tumor
cell proliferation and tumor vascularization.;
Molecule name : BL-M07D1; BL M07D1;
NCI Metathesaurus CUI : CL1798648;
Origin ID : C189821;
UMLS CUI : C5706553;
Semantic type(s)
- concept_is_in_subset
- has_target
