Preferred Label : HER2 Inhibitor DZD1516;
NCIt definition : An orally bioavailable, blood brain barrier (BBB) penetrable inhibitor of the receptor
tyrosine kinase human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with
potential antineoplastic activity. Upon oral administration, HER2 inhibitor DZD1516
selectively binds to and inhibits the activity of HER2. This prevents HER2-mediated
signaling and leads to cell death in HER2-expressing tumor cells. HER2, a receptor
tyrosine kinase overexpressed on a variety of tumor cell types, plays an important
role in tumor cell proliferation and tumor vascularization.;
Molecule name : DZD 1516; DZD-1516;
NCI Metathesaurus CUI : CL1407916;
Origin ID : C174039;
UMLS CUI : C5418056;
Semantic type(s)
- concept_is_in_subset
- has_target
