Preferred Label : Anti-HER2 Antibody-drug Conjugate BAT8010;
NCIt synonyms : Anti-HER2 ADC BAT8010;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2) linked to the camptothecin analog exatecan, with potential antineoplastic
activity. Upon administration of anti-HER2 ADC BAT8010, the anti-HER2 monoclonal antibody
moiety targets and binds to HER2 expressed on tumor cells. Upon binding, internalization
and linker cleavage, exatecan is released. Exatecan inhibits DNA topoisomerase I activity,
thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell
apoptosis. This inhibits the proliferation of HER2-expressing tumor cells. HER2, a
receptor tyrosine kinase that is mutated or overexpressed in many tumor cell types,
plays an important role in tumor cell proliferation and tumor vascularization.;
Molecule name : BAT 8010; BAT-8010;
NCI Metathesaurus CUI : CL1906990;
Origin ID : C200154;
UMLS CUI : C5854485;
Semantic type(s)
- concept_is_in_subset
- has_target
