NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human
epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating
and antineoplastic activities. Upon administration, autologous anti-HER2 CAR T-cells
CCT303-406 target and bind to HER2-expressing tumor cells, thereby inducing selective
toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer
cell types and is associated with increased tumor cell proliferation.;