Preferred Label : pNGVL3-hICD Vaccine;
NCIt synonyms : pNGVL3-hHER2 Intracellular Domain Plasmid DNA Vaccine;
NCIt definition : A plasmid DNA cancer vaccine encoding the intracellular domain (ICD) of the HER-2/neu
proto-oncogene. Upon administration and after cellular uptake by skin or muscle cells,
the pNGVL3-hICD vaccine plasmid expresses the HER-2/neu protein, which, after intracellular
processing, may elicit both antigen-specific cytotoxic T-lymphocyte (CTL) and humoral
immune responses against tumor cells expressing HER-2. The HER-2/neu ICD protein is
highly immunogenic and, as a subdominant epitope, may be associated with decreased
immune tolerance.;
Origin ID : C61146;
UMLS CUI : C1831753;
Semantic type(s)
- concept_is_in_subset
- has_target
