NCIt definition : A full-length IgG1 bispecific antibody with enhanced antibody-dependent cellular cytotoxicity
(ADCC) directed against human epidermal growth factor receptor 2 (HER2; EGFR2, ERBB2)
and human epidermal growth factor receptor 3 (HER3; ErbB3), with potential antineoplastic
activity. Upon intravenous administration of zenocutuzumab, the bispecific antibody
docks on HER2, and subsequently blocks heregulin-stimulated proliferation of tumor
cells by binding HER3. In addition to inhibiting HER3-dependent signaling, simultaneous
targeting of HER2 and HER3 by zenocutuzumab may overcome a common resistance mechanism
driven by heregulin-mediated dimerization of HER2 and HER3. Zenocutuzumab is expected
to eliminate tumor cells by recruiting natural killer (NK) cells to tumor cells coated
with the bispecific antibody.;
UNII : AE72RB1W1X;
CAS number : 1969309-56-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1969309-56-5
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