Preferred Label : HER2 ECD TM Virus-like Replicon Particles Vaccine AVX901;
NCIt synonyms : HER2 ECDTM VRP; VRP-HER2 ECDTM; Alphavirus-like Replicon Particles-containing Self Amplifying Replicon RNA for HER2
AVX901; VRP-HER2 AVX901;
NCIt definition : A cancer vaccine based on virus-like replicon particles (VRP) packaged with an alphaviral
vector encoding the extracellular domain (ECD) and transmembrane (TM) regions of the
human epidermal growth factor receptor 2 (EGFR2, NEU or HER2), with potential antineoplastic
activity. After immunization with HER2 ECD TM virus-like replicon particles vaccine
AVX901, the VRPs infect cells and express HER2 ECD TM protein that may activate the
immune system to elicit a cytotoxic T-lymphocyte (CTL) response against HER2-expressing
tumor cells. The alphaviral replicon of this vaccine is an attenuated strain of the
Venezuelan equine encephalitis virus (VEEV) in which 3 of the 7 viral genes were substituted
with a truncated HER2 gene to create a self-amplifying replicon RNA. HER2, a tyrosine
kinase involved in several cell growth signaling pathways, is dysregulated or overexpressed
in a wide variety of cancer cell types.;
Molecule name : AVX-901; AVX 901;
NCI Metathesaurus CUI : CL433604;
Origin ID : C99903;
UMLS CUI : C3275039;
Semantic type(s)
- concept_is_in_subset
- has_target
