Preferred Label : Allogeneic Anti-HER2 CAR-NK Cells AB-201;
NCIt synonyms : Allogeneic Anti-HER2 CAR-Natural Killer Cells AB-201; Allogeneic Anti-HER2 CAR-NKs AB-201;
NCIt definition : A preparation of allogeneic, off-the-shelf (OTS), natural killer (NK) cells derived
from cord blood (CB), ex vivo expanded and genetically modified to express a chimeric
antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human epidermal
growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunomodulating and
antineoplastic activities. Upon administration, allogeneic anti-HER2 CAR-NK cells
AB-201 recognize, bind to and induce selective cytotoxicity in HER2-expressing tumor
cells. HER2 is overexpressed in a variety of cancer cell types and is associated with
increased tumor cell proliferation.;
Molecule name : AB-201; AB 201;
Origin ID : C212933;
concept_is_in_subset
- has_target
