Preferred Label : HER2-targeting Antibody Fc Fragment FS102;
NCIt synonyms : Anti-HER2 FCAB FS102; Fcab FS102;
NCIt related terms : FS-102;
NCIt definition : A proprietary, antibody fragment composed of a constant (Fc) region that is engineered
to bind to the tumor-associated antigen human epidermal growth factor receptor-2 (HER2),
with potential antineoplastic activity. HER2-targeted antibody Fc fragment FS102 specifically
binds to its HER2 epitope, and causes downregulation of HER2-mediated signaling. This
leads to tumor cell apoptosis. HER2, a member of the receptor tyrosine kinase (RTK)
epidermal growth factor receptor (EGFR) superfamily, is overexpressed on the cell
surface of various solid tumors.;
UNII : Z27ZI1MZY9;
Molecule name : BMS-986186; FS102;
Origin ID : C118953;
UMLS CUI : C3896857;
Semantic type(s)
- concept_is_in_subset
- has_target
