Preferred Label : Zirconium Zr 89-ss-Pertuzumab;
NCIt synonyms : Site-specifically Labeled 89Zr-Pertuzumab; 89Zr-ss-Pertuzumab; Zr 89-ss-Pertuzumab;
NCIt definition : A radioimmunoconjugate composed of pertuzumab, a humanized recombinant monoclonal
antibody directed against the extracellular dimerization domain of the tyrosine kinase
receptor human epidermal growth factor-2 (HER2; HER-2), and linked, using a site-specific
bioconjugation method, to the radioisotope zirconium Zr 89 (Zr89), with potential
use in the imaging of HER-2-expressing tumor cells upon positron emission tomography
(PET). Upon administration of zirconium Zr 89-ss-pertuzumab, the pertuzumab moiety
targets and binds to HER-2. After binding and internalization into HER-2-expressing
tumor cells, Zr89 facilitates the visualization and detection of HER-2-expressing
tumor cells using PET. This assesses HER2-expression and may predict or evaluate the
tumor's response to certain HER-2-targeting chemotherapeutics. Site-specific bioconjugation
may produce better defined and more homogeneous radioimmunoconjugates.;
NCI Metathesaurus CUI : CL1643091;
Origin ID : C177157;
UMLS CUI : C5447601;
Semantic type(s)
- concept_is_in_subset
- has_target
