Preferred Label : Gozanertinib;
NCIt synonyms : EGFR/HER2 Inhibitor ABT-101;
NCIt definition : An orally bioavailable dual kinase inhibitor of epidermal growth factor receptor (EGFR;
ErbB1) and human epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2), including
EGFR L858R, EGFR T790M and HER2 exon 20 insertion (Ex20ins) mutations, with potential
antineoplastic activity. Upon oral administration, gozanertinib targets, binds to
and inhibits the activity of EGFR or HER2 insertions or mutations. This prevents EGFR/HER2-mediated
signaling, which may induce cell death and inhibit tumor growth in EGFR/HER2-overexpressing
tumor cells. The ErbB receptor tyrosine kinase family is involved in key cellular
functions, including cell growth and survival. EGFR and HER2 alterations constitutively
upregulate kinase activity.;
UNII : 6G0COS33K4;
CAS number : 1226549-49-0;
Molecule name : DBPR 112; DBPR-112; ABT-101; ABT 101;
NCI Metathesaurus CUI : CL554867;
Origin ID : C153427;
UMLS CUI : C5787202;
Semantic type(s)
- concept_is_in_subset
- has_target
