Preferred Label : Anti-HER2/Topoisomerase I Inhibitor ADC GQ1005;
NCIt synonyms : ADC GQ1005; Anti-HER2 Antibody-drug Conjugate GQ1005; Anti-HER2/TOP1i ADC GQ1005;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2;
HER2; ErbB2) conjugated, via a cleavable open-ring linker, to a topoisomerase I (TopoI)
inhibitor-based payload, with potential antineoplastic activity. Upon administration
of the anti-HER2/topoisomerase I inhibitor ADC GQ1005, the anti-HER2 monoclonal antibody
moiety targets and binds to HER2 expressed on tumor cells. Upon cellular uptake, the
TopoI inhibitor inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
which results in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of HER2-expressing tumor cells. Also, GQ1005 induces an additional bystander effect,
thereby further killing tumor cells. HER2, a tyrosine kinase receptor, is overexpressed
by many cancer cell types.;
Molecule name : GQ 1005; GQ-1005;
NCI Metathesaurus CUI : CL1927041;
Origin ID : C204803;
UMLS CUI : C5908060;
Semantic type(s)
- concept_is_in_subset
- has_target
