Preferred Label : Autologous Anti-HER2 CAR Monocytes CT-0525;
NCIt synonyms : Autologous Anti-HER2 CAR-monocytes CT-0525; Autologous Anti-HER2 CAR-Mono CT-0525;
NCIt definition : A preparation of autologous monocytes genetically modified to express a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen (TAA) human epidermal growth
factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic
activities. Upon administration, autologous anti-HER2 CAR monocytes CT-0525 specifically
recognize and bind to HER2-expressing tumor cells, and expose the immune system to
the HER2 antigen. This may elicit a cytotoxic T-lymphocyte (CTL) response against
HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types
and is associated with increased tumor cell proliferation.;
Molecule name : CT 0525; CT-0525;
NCI Metathesaurus CUI : CL1928301;
Origin ID : C205637;
concept_is_in_subset
- has_target
