Preferred Label : Autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-expressing CD4 /CD8 T-cells SC-CAR4BRAIN;
NCIt synonyms : Autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-T Cells SC-CAR4BRAIN; SC-CAR4BRAIN; Autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR T Cells SC-CAR4BRAIN;
NCIt definition : A preparation of autologous CD4 and CD8 T-lymphocytes transduced with a lentiviral
vector to express four chimeric antigen receptors (CARs) targeting the immunoregulatory
protein B7-homologue 3 (B7-H3, CD276), epidermal growth factor receptor (EGFR) mAb806
epitope, human epidermal growth factor 2 (HER2; ErbB2; HER-2), and interleukin-13
receptor alpha 2 (IL13Ra2), with potential immunostimulating and antineoplastic activities.
Upon administration, autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-expressing CD4
/CD8 T-cells SC-CAR4BRAIN target and bind to tumor cells that express B7-H3, EGFR
mAb806 epitope, HER2 and IL13Ra2, thereby inducing selective toxicity in these cells.
B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein
superfamily, is overexpressed on certain tumor cell types and on various immune cells.
It is a negative regulator of T-cell activation and its overexpression plays a key
role in tumor cell invasion and metastasis. EGFR, overexpressed by a variety of cancer
cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio-
and chemoresistance. EGFR806 CAR specifically targets abnormal conformational states
of EGFR, including EGFR deletion mutation variant III (EGFRvIII), and activating mutations,
with lower affinity for wild-type EGFR. HER2 is overexpressed in a variety of cancer
cell types and is associated with increased tumor cell proliferation. IL13Ra2, a cancer-associated
receptor, is overexpressed by a variety of tumor cell types including glioblastoma
multiforme (GBM); it is associated with increased invasiveness of tumor cells.;
NCI Metathesaurus CUI : CL1907098;
Origin ID : C200272;
UMLS CUI : C5856947;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
