Copper Cu 64-DOTA-Trastuzumab

Preferred Label : Copper Cu 64-DOTA-Trastuzumab;

NCIt synonyms : 64Cu-DOTA-Trastuzumab;

NCIt definition : A radioimmunoconjugate containing the recombinant humanized monoclonal antibody trastuzumab conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with the radioisotope copper Cu 64 with radioisotopic activity and potential use as an imaging agent. The trastuzumab moiety of copper Cu 64-DOTA-trastuzumab binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2). Upon binding, the radioisotope moiety may be detected using positron emission tomography (PET), thereby allowing the imaging and quantification of HER2-expressing tumor cells. HER2, a tyrosine kinase and client protein of heat shock protein 90 (Hsp90), may be overexpressed on the cell surfaces of various tumor cell types.;

Details

Origin ID

C90576;

UMLS CUI

C2745103;

Currated CISMeF NLP mapping
- 64Cu-DOTA-trastuzumab [MeSH concept]
- 64Cu-DOTA-trastuzumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 64Cu-DOTA-trastuzumab [MeSH concept]
- 64Cu-DOTA-trastuzumab [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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