Pyrotinib - CISMeF

Preferred Label : Pyrotinib;

NCIt definition : An orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization.;

UNII : CJN36EQM0H;

CAS number : 1269662-73-8;

Molecule name : SHR 1258; SHR-1258;

NCI Metathesaurus CUI : CL454228;

Codes from synonyms : 111427;

Details

Origin ID

C111895;

UMLS CUI

C3828434;

Automatic exact mappings (from CISMeF team)
- pyrotinib [MeSH concept]
Currated CISMeF NLP mapping
- pyrotinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- pyrotinib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Pyrotinib Dimaleate [NCIt concept]
has_target
- Epidermal Growth Factor Receptor [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
is_free_acid_or_base_form_of
- Pyrotinib Dimaleate [NCIt concept]

Keyword's position in hierarchy(ies) :

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