NCIt definition : An orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor
(EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2),
with potential antineoplastic activity. Upon oral administration, pyrotinib binds
to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth
and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and
HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types
and play major roles in tumor cell proliferation and tumor vascularization.;
UNII : CJN36EQM0H;
CAS number : 1269662-73-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1269662-73-8
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