NCIt definition : The dimaleate ester of pyrotinib, an orally bioavailable, dual kinase inhibitor of
the epidermal growth factor receptor (EGFR, ErbB1 or HER-1) and the human epidermal
growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity.
Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which
may result in the inhibition of tumor growth and angiogenesis, and tumor regression
in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that
are upregulated in various tumor cell types and play major roles in tumor cell proliferation
and tumor vascularization.;
Semantic type(s)