Preferred Label : Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine;
NCIt synonyms : HER-2 pulsed DC vaccine; autologous dendritic cell/adenovirus HER-2 vaccine; Autologous Dendritic Cell-Adenovirus HER2 Vaccine; AdHer2/DC; Adenovirus-transduced HER-2 Autologous Dendritic Cell Vaccine;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced
with a replication-deficient adenovirus vector encoding HER-2 with potential antineoplastic
activity. Upon administration, adenovirus HER2-transduced autologous dendritic cell
vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against HER-2-positive
tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2,
a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and
ErbB2), is overexpressed by some breast, ovarian, and gastric cancers.;
Origin ID : C61098;
UMLS CUI : C1831756;
Semantic type(s)
- concept_is_in_subset
- has_target
