Masoprocol - CISMeF

Preferred Label : Masoprocol;

NCIt synonyms : 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]; NDHGA;

NCIt related terms : Actinex; NDGA; Nordihydroguaiaretic acid;

NCIt definition : A naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. Masoprocol directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, masoprocol inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrienes. It may prevent leukocyte infiltration into tissues and the release of reactive oxygen species.;

Alternative definition : NCI-GLOSS: A drug put on the skin to treat growths caused by sun exposure. A form of Masoprocol that is taken by mouth is being studied in the treatment of prostate cancer. Masoprocol is an antioxidant, and it may block certain enzymes needed for tumor growth.;

UNII : 7BO8G1BYQU;

InChIKey : HCZKYJDFEPMADG-TXEJJXNPSA-N;

CAS number : 27686-84-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 27686-84-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Actinex;

Chemical formula : C18H22O4;

NSC code : 4291;

Codes from synonyms : CDR0000523328; NSC0004291; CDR0000523329; 00617; CDR0000523330;

PubMed : 8450672;

Details

Origin ID

C701;

UMLS CUI

C0733397;

Automatic exact mappings (from CISMeF team)
- Actin [LOINC component]
- Masoprocol [ICD-11 Extension code]
- actins [MeSH Descriptor]
Currated CISMeF NLP mapping
- Masoprocol (substance) [SNOMED CT concept]
- masoprocol [Substance BNPC]
- masoprocol [MeSH Descriptor]
- masoprocol [MeSH concept]
See also inter- (CISMeF)
- Product containing masoprocol (medicinal product) [SNOMED CT concept]
- nordihydroguaiaretic acid [Substance BNPC]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Masoprocol (substance) [SNOMED CT concept]
- Product containing masoprocol (medicinal product) [SNOMED CT concept]
- masoprocol [ATC Code]
- masoprocol [MeSH concept]
- masoprocol [MeSH Descriptor]
- nordihydroguaiaretic acid [Substance BNPC]
Validated automatic mappings to BTNT
- masoprocol [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Arachidonate 5-Lipoxygenase [NCIt concept]
- Insulin-Like Growth Factor 1 Receptor [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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