Preferred Label : Masoprocol;
NCIt synonyms : 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]; NDHGA;
NCIt related terms : Actinex; NDGA; Nordihydroguaiaretic acid;
NCIt definition : A naturally occurring antioxidant dicatechol originally derived from the creosote
bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities.
Masoprocol directly inhibits activation of two receptor tyrosine kinases (RTKs), the
insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting
in decreased proliferation of susceptible tumor cell populations. This agent may induce
apoptosis in susceptible tumor cell populations as a result of disruption of the actin
cytoskeleton in association with the activation of stress activated protein kinases
(SAPKs). In addition, masoprocol inhibits arachidonic acid 5-lipoxygenase (5LOX),
resulting in diminished synthesis of inflammatory mediators such as prostaglandins
and leukotrienes. It may prevent leukocyte infiltration into tissues and the release
of reactive oxygen species.;
Alternative definition : NCI-GLOSS: A drug put on the skin to treat growths caused by sun exposure. A form
of Masoprocol that is taken by mouth is being studied in the treatment of prostate
cancer. Masoprocol is an antioxidant, and it may block certain enzymes needed for
tumor growth.;
UNII : 7BO8G1BYQU;
InChIKey : HCZKYJDFEPMADG-TXEJJXNPSA-N;
CAS number : 27686-84-6;
Drug name : Actinex;
Chemical formula : C18H22O4;
NSC code : 4291;
Codes from synonyms : CDR0000523328; NSC0004291; CDR0000523329; 00617; CDR0000523330;
PubMed : 8450672;
Origin ID : C701;
UMLS CUI : C0733397;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
