Preferred Label : Sevabertinib;
NCIt synonyms : EGFR/HER2 Mutant-selective Inhibitor BAY2927088;
NCIt definition : An orally bioavailable, mutant-selective, dual kinase inhibitor of epidermal growth
factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with potential
antineoplastic activity. Upon oral administration, sevabertinib targets, binds to,
and inhibits the activity of EGFR and HER2 with exon20 insertion mutations, as well
as EGFR with C797X mutations, thereby preventing EGFR- and HER2-mediated signaling.
This may result in the inhibition of tumor growth and angiogenesis, and tumor regression
in EGFR/HER2-expressing tumors. EGFR and HER2 are receptor tyrosine kinases that play
major roles in tumor cell proliferation and tumor vascularization.;
UNII : 2A7VPM5RWH;
CAS number : 2521285-05-0;
Molecule name : BAY 2927088; BAY-2927088;
NCI Metathesaurus CUI : CL1773419;
Origin ID : C185187;
UMLS CUI : C5666959;
Semantic type(s)
- concept_is_in_subset
- has_target
