Preferred Label : EGFR/HER2 Mutant-selective Inhibitor BAY2927088;
NCIt definition : An orally bioavailable, mutant-selective, dual kinase inhibitor of epidermal growth
factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with potential
antineoplastic activity. Upon oral administration, EGFR/HER2 mutant-selective inhibitor
BAY2927088 targets, binds to, and inhibits the activity of EGFR and HER2 with exon20
insertion mutations, as well as EGFR with C797X mutations, thereby preventing EGFR-
and HER2-mediated signaling. This may result in the inhibition of tumor growth and
angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. EGFR and HER2 are
receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor
vascularization.;
Molecule name : BAY 2927088; BAY-2927088;
NCI Metathesaurus CUI : CL1773419;
Origin ID : C185187;
UMLS CUI : C5666959;
Semantic type(s)
- concept_is_in_subset
- has_target
