Trastuzumab Emtansine

Preferred Label : Trastuzumab Emtansine;

NCIt synonyms : Trastuzumab-MCC-DM1 Antibody-Drug Conjugate; Trastuzumab-MCC-DM1; Trastuzumab-DM1; T-DM1; Trastuzumab-MCC-DM1 Immunoconjugate; Ado Trastuzumab Emtansine; Trastuzumab-MCC-DM1 Conjugate; Immunoglobulin G1, Anti-(Human p185neu Receptor) (Human-Mouse Monoclonal RhuMab HER2 Gamma1-Chain), Disulfide with Human-Mouse Monoclonal RhuMab HER2 Light Chain, Dimer, Tetraamide with N2'-(3-((1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)thio)-1-oxopropyl)-N2'-deacetylMaytansine; ADO-Trastuzumab Emtansine; TDM1;

NCIt definition : An antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers.;

UNII : SE2KH7T06F;

CAS number : 1018448-65-1;

Drug name : Kadcyla;

Molecule name : PRO-132365; RO5304020; PRO 132365;

Chemical formula : C47H63ClN5O13S;

Codes from synonyms : 12;

Details

Origin ID

C82492;

UMLS CUI

C2935436;

CISMeF manual mappings
- Trastuzumab emtansine (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ado-Trastuzumab Emtansine [MeSH Descriptor]
- Product containing trastuzumab emtansine (medicinal product) [SNOMED CT concept]
- Trastuzumab emtansine (substance) [SNOMED CT concept]
- ado-trastuzumab emtansine [MeSH concept]
- trastuzumab emtansine [ATC Code]
- trastuzumab emtansine [International Nonproprietary Name]
Validated automatic mappings to BTNT
- trastuzumab emtansine [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Ado-trastuzumab Emtansine Regimen [NCIt concept]
- Trastuzumab Emtansine Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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