NCIt definition : A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic
activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors
(EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction
and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress
these receptors.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called epidermal growth factor receptor inhibitors.;